No vitamin D threshold for calcium absorption: why does this matter?

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No vitamin D threshold for calcium absorption: why does this matter?

It has long been known that 1,25-dihydroxyvitamin D stimulates calcium absorption and that there is a correlation between serum 25-hydroxyvitamin D [25(OH)D] and calcium absorption at low serum concentrations when transcellular processes are more important (1). Calcium absorption has been used as one of several measures to determine vitamin D intake requirements or sufficiency (2). Previously, ...

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Vitamin D supplementation increases calcium absorption without a threshold effect.

BACKGROUND The maximal calcium absorption in response to vitamin D has been proposed as a biomarker for vitamin D sufficiency. OBJECTIVE The objective was to determine whether there is a threshold beyond which increasing doses of vitamin D, or concentrations of serum 25-hydroxyvitamin D [25(OH)D], no longer increase calcium absorption. DESIGN This was a placebo-controlled, dose-response, ra...

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Role of vitamin D-dependent and vitamin D-independent mechanisms in absorption of food calcium.

We measured net calcium absorption and the calcium content of the digestive glands secretions in people with widely different serum concentrations of 1,25 dihydroxy vitamin D (hereafter referred to a 1,25-D). Patients with end stage renal disease on hemodialysis served as a model of human 1,25-D deficiency; they were also studied when they had abnormally high serum 1,25-D concentrations as a re...

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 2014

ISSN: 0002-9165,1938-3207

DOI: 10.3945/ajcn.113.082644